Inhibitory Effect of Progesterone on the Phytohaemagglutinin-Induced Transformation of Human Peripheral Lymphocytes
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 4 (6), 519-527
- https://doi.org/10.3109/08820137509055790
Abstract
Effect of sex steroids, progesterone and estradiol-17β, on transformation of human lymphocytes induced by PHA was investigated. Responses of peripheral lymphocytes from non-pregnant women to PHA was markedly reduced in the presence of progesterone at a concentration of 103 or 104ng/ml. Estradiol-178, on the other hand, had no effects on the PHA-induced transformation under the present experimental conditions. The immunosuppressive property of progesterone may contribute to depression of maternal cell-mediated immunity against fetus during pregnancy.This publication has 11 references indexed in Scilit:
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