Computer-Predicted Theophylline Kinetics
- 1 September 1983
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (9), 557-559
- https://doi.org/10.1056/nejm198309013090915
Abstract
To the Editor: In the March 31 issue Weinberger and Hendeles1 proposed that the rate of absorption of sustained-release theophylline preparations is essentially constant in different individuals for each preparation, so that absorption rates calculated from single-dose pharmacokinetic studies of different sustained-release theophylline preparations in different groups of subjects may be used to predict steady-state peak–trough blood-level fluctuations in patients with known or predicted rates of drug elimination. No data are presented to support the computer model based on this hypothesis. In an earlier paper these authors compared predicted with measured levels only for plain theophylline tablets given every six . . .Keywords
This publication has 9 references indexed in Scilit:
- Sustained-Release TheophyllineAmerican Journal of Diseases of Children, 1983
- ASTHMA AT NIGHTThe Lancet, 1983
- Slow-Release Theophylline Rationale and Basis for Product SelectionNew England Journal of Medicine, 1983
- Theophylline A “State of the Art” ReviewPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1983
- Relative Bioavailability of Two Sustained-Release Theophylline Formulations versus an Immediate-Release PreparationJournal of Asthma, 1983
- Delay in the absorption rate of theophylline from a sustained release theophylline preparation caused by food.British Journal of Clinical Pharmacology, 1981
- Sustained-release theophylline for childhood asthma: Evidence for circadian variation of theophylline pharmacokineticsThe Journal of Pediatrics, 1981
- Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthmaThe Journal of Pediatrics, 1981
- A new in vitro dissolution test for controlled-release theophylline tabletsInternational Journal of Pharmaceutics, 1981