Computer-Predicted Theophylline Kinetics

Abstract

To the Editor: In the March 31 issue Weinberger and Hendeles¹ proposed that the rate of absorption of sustained-release theophylline preparations is essentially constant in different individuals for each preparation, so that absorption rates calculated from single-dose pharmacokinetic studies of different sustained-release theophylline preparations in different groups of subjects may be used to predict steady-state peak–trough blood-level fluctuations in patients with known or predicted rates of drug elimination. No data are presented to support the computer model based on this hypothesis. In an earlier paper these authors compared predicted with measured levels only for plain theophylline tablets given every six . . .