THE carpal tunnel syndrome, a compression neuropathy, has been accepted as a neurological complication of myxedema.1,2An intrinsic neuropathy secondary to myxedema has been suggested but not as yet clearly proven.3In an effort to elucidate this latter condition a study of median and ulnar sensory nerve potentials has been done in myxedematous patients. Methods Sixteen patients with an unequivocal diagnosis of myxedema established by clinical and laboratory criteria were included in this survey. Their ages ranged from 30 to 84 years (average age 56). Median and ulnar evoked sensory nerve potentials were sought in all of these patients in a manner similar to that outlined by Dawson and Scott.4Stimulating electrodes were placed about the second and third digits for median nerve determinations and about the fourth and fifth digits for ulnar nerve determinations. The stimulating cathode was located at the metacarpal phalangeal joints while the