Estimation of Adrenomedullary Reserve by Infusion of 2-Deoxy-d-glucose
- 1 January 1966
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 26 (1), 37-45
- https://doi.org/10.1210/jcem-26-1-37
Abstract
Infusions of 2-deoxy-D-glucose (2-DG), in concentrations of 50 mg/kg body wt, produced a consistent and pronounced increase in urinary epinephrine output in subjects with intact adrenal glands. They also produced a significant rise in urinary epinephrine in patients with Addison''s disease classified as idiopathic by clinical criteria, but not in those whose disease was considered tuberculous in origin, or in subjects with adrenalectomy or thoracolumbar sympathectomy. A rise in blood glucose has been demonstrated to correlate well with the increase in urinary epinephrine that follows 2-DG administration. Measurement of these substances affords a clinically useful means for evaluating the functional capacity of the adrenal medulla.This publication has 1 reference indexed in Scilit:
- Addison's Disease in Association With AmyloidosisAnnals of Internal Medicine, 1928