Transcriptional noise and the fidelity of initiation by RNA polymerase II
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- 1 February 2007
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 14 (2), 103-105
- https://doi.org/10.1038/nsmb0207-103
Abstract
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function.Keywords
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