Electrochemical Glucose Oxidation on a Platinized Platinum Electrode in Krebs‐Ringer Solution: III . Effect of Urea

Abstract

The anodic oxidation of glucose and urea on a platinized platinum rotating disk electrode was studied by linear and triangular sweep voltammetry in a modified Krebs‐Ringer solution. When glucose was the only reactant, three distinct potential regions of glucose oxidation existed in the current‐potential curve. When urea was the only reactant, a small steady‐state oxidation current was observed at high potentials, and strong adsorption effects were evident. When both glucose and urea were present, glucose oxidation was strongly inhibited. Conditions were found which provided an unequivocal relationship between glucose concentration and measured current, with a minimal effect of changes in urea concentration. These results are promising for the development of an implantable electrochemical glucose sensor.