THE EFFECT OF SERUM FROM INSULIN-RESISTANT CASES ON THE COMBINATION OF INSULIN WITH THE RAT DIAPHRAGM 1
Open Access
- 1 January 1952
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 31 (1), 107-110
- https://doi.org/10.1172/jci102567
Abstract
The ability of human serum to influence the combination of insulin with the isolated rat diaphragm has been studied. The combina- tion of insulin with the diaphragm, as measured by its effect on glycogen synthesis, was found to be significantly decreased in the presence of serum from normal or diabetic individuals. Serum evidently contains substances which combine with or inactivate insulin. Serum from insulin-resistant patients appears to contain greatly increased amts. of such substances.Keywords
This publication has 3 references indexed in Scilit:
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- INSULIN RESISTANCE ASSOCIATED WITH LOCAL AND GENERAL ALLERGY TO INSULINJAMA, 1951
- IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE II. THE PRESENCE OF A NEUTRALIZING FACTOR IN THE BLOOD EXHIBITING SOME CHARACTERISTICS OF AN ANTIBODYJCI Insight, 1944