Chitosan microcapsules as controlled release systems for insulin
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 14 (5), 567-576
- https://doi.org/10.3109/02652049709006810
Abstract
This study analyses the use of chitosan for the production of surface crosslinked microparticulate systems containing insulin. The microcapsules were prepared by an innovative technique based on interfacial crosslinkage of different amounts of chitosan solubilized in the inner phase of a water/oil emulsion by means of ascorbyl palmitate. The correlation between the main formulation parameters and the functional properties of the microcapsules were analysed. Insulin is incorporated with high efficiency. The peptide release is constant for appreciable periods of time. The content of chitosan modulates the main physico-chemical properties of the matrix.Keywords
This publication has 17 references indexed in Scilit:
- Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kineticsJournal of Microencapsulation, 1996
- Preparation and evaluation of cross-linked chitosan microspheres containing furosemideInternational Journal of Pharmaceutics, 1994
- Factors influencing the release of peptides and proteins from biodegradable parenteral depot systemsJournal of Controlled Release, 1992
- Nanocapsules as carriers for oral peptide deliveryJournal of Controlled Release, 1990
- Release characteristics of cisplatin chitosan microspheres and effect of containing chitin.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- Release of Human Serum Albumin from Poly(lactide-co-glycolide) MicrospheresPharmaceutical Research, 1990
- Solvent selection in the preparation of poly(dl-lactide) microspheres prepared by the solvent evaporation methodInternational Journal of Pharmaceutics, 1988
- Prolonged delivery of peptides by microcapsulesJournal of Controlled Release, 1987
- Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. I. Methods and morphologyJournal of Microencapsulation, 1987
- Lysozyme degradation of partially deacetylated chitin, its films and hydrogelsBiomaterials, 1982