INACTIVATION OF STILBESTROL BY LIVER IN VITRO1
- 1 December 1943
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 33 (6), 333-336
- https://doi.org/10.1210/endo-33-6-333
Abstract
Contrary to earlier results, stilbestrol is inactivated by liver pulp in vitro but less rapidly than is estrone. Within a specified time twice as much liver is required to inactivate stilbestrol as estrone. It is suggested that this finding explains the greater oral efficiency and the toxic side-effects of stilbestrol in man. In rats, treated with large amts. of stilbestrol, the capacity of the liver to inactivate stilbestrol is increased.This publication has 4 references indexed in Scilit:
- INACTIVATION OF ESTRONE AND DIETHYLSTILBESTROL BY MICROORGANISMS1,2Endocrinology, 1943
- The Oxidation of Estrogens by PhenolasesProceedings of the National Academy of Sciences, 1941
- Phenol methyl ethers as oestrogenic agentsBiochemical Journal, 1938
- Über das Schicksal des Follikelhormons (Follikulin) im Organismus1Skandinavisches Archiv Für Physiologie, 1934