Stereochemical studies. Part 86. Saturated heterocycles. Part 81. Preparation of new thiouracils via retrodiene decomposition of methylene-bridged quinazolone thiones
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2483-2487
- https://doi.org/10.1039/p19850002483
Abstract
endo- and exo-Norbornene (1) and (3) and norbornane (2) and (4) amino acids and isothiocyanates give methylene-bridged 2-thioxohexahydro-(10) and (11) and octahydro-(12) and (13)-quinazolin-4-ones. Compounds (10) and (11) decompose in a retro-Diels-Alder reaction when heated to melting, to give new 3-substituted thiouracils (14a–e); no convenient general suitable method was previously known for the preparation of these compounds.This publication has 4 references indexed in Scilit:
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