Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase
- 1 October 1985
- journal article
- research article
- Published by Elsevier in Molecular and Biochemical Parasitology
- Vol. 17 (1), 79-91
- https://doi.org/10.1016/0166-6851(85)90129-x
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.Journal of Biological Chemistry, 1985
- Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropicaBiochemistry, 1985
- Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilizationCell, 1984
- A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoaMolecular and Biochemical Parasitology, 1984
- Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cellsBiochemical Pharmacology, 1983
- Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.Proceedings of the National Academy of Sciences, 1983
- Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.Molecular and Cellular Biology, 1981
- A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in miceEuropean Journal of Cancer (1965), 1981
- Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.Proceedings of the National Academy of Sciences, 1980