Demonstration of an Anoxic Component in a Mouse Tumor-Cell Population by in Vivo Assay of Survival Following Irradiation

Abstract

The sensitivity of cells of the 6C3HED mouse lymphosarcoma to 220-kv X-rays is measured under a variety of conditions designed to alter the oxygen tension to which the cells are subjected. It is concluded that when growing subcutaneously in the flank of the mouse, the tumor- cell population is heterogeneous with respect to degree of oxygenation.