Significance of Methicillin Tolerance in Experimental Staphylococcal Endocarditis
Open Access
- 1 June 1979
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 15 (6), 802-806
- https://doi.org/10.1128/aac.15.6.802
Abstract
Methicillin-tolerant staphylococci are organisms that are inhibited by low concentrations of the drug but are resistant to its bactericidal effects. The clinical significance of this in vitro phenomenon is unknown. An experimental model of staphylococcal endocarditis in rabbits was used to determine whether methicillin-tolerant staphylococci are particularly difficult to eradicate from infected heart valves. In vitro sensitivity testing was used to identify a tolerant and a nontolerant strain of Staphylococcus aureus . Rabbits prepared by the insertion of a polyethylene catheter into the left ventricle and injected with a tolerant strain survived significantly longer than those injected with a nontolerant strain. No significant differences were demonstrated in the prevention of endocarditis with a single prophylactic dose of methicillin, or in the treatment of established endocardial infection with multiple doses of methicillin. In this study, methicillin had the same activity against experimental endocarditis caused by a tolerant and a nontolerant strain of S. aureus .This publication has 19 references indexed in Scilit:
- Persistent bacteremia in staphylococcal endocarditisAmerican Journal Of Medicine, 1978
- Antibiotic-tolerant Staphylococcus aureusJournal of Antimicrobial Chemotherapy, 1978
- Medium-Dependent Variation in Bactericidal Activity of Antibiotics Against Susceptible Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1978
- A NEW TYPE OF PENICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUSThe Lancet, 1977
- Susceptibility of clinical isolates of Staphylococcus aureus to killing by oxacillinCanadian Journal of Microbiology, 1975
- Evidence for Participation of Autolysins in Bactericidal Action of Oxacillin on Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1974
- MODE OF RESISTANCE AGAINST β‐LACTAM ANTIBIOTICS IN STAPHYLOCOCCIAnnals of the New York Academy of Sciences, 1971
- Multiple Antibiotic Resistance in a Bacterium with Suppressed Autolytic SystemNature, 1970
- PENICILLINASE PRODUCTION AND INTRINSIC RESISTANCE TO PENICILLINS IN STAPHYLOCOCCUS AUREUSThe Lancet, 1966
- Persistence of Staphylococcus aureus in Penicillin in vitroJournal of General Microbiology, 1964