Inhibition of Brain Respiration by Ethyl Alcohol at Varied Temperature Levels

Abstract

Summary The inhibition of oxygen consumption of rat cerebral cortex slices by ethyl alcohol was studied at 37.7 C, 30 C and 20 C. The inhibition becomes progressively greater with time at 37.7 C; such progressive inhibition is less marked at 30 C and is absent at 20 C. The minimum effective inhibitory concentration increases with decrease in temperature. The percentage inhibition with a given concentration of alcohol decreases with decrease in temperature.