Sterol-Inhibiting Fungicides: Effects on Sterol Biosynthesis and Sites of Action
- 1 January 1981
- journal article
- research article
- Published by Scientific Societies in Plant Disease
- Vol. 65 (12), 986-989
- https://doi.org/10.1094/pd-65-986
Abstract
A group of fungicides (diverse with respect to chemical structure, spectrum of biological activity and degree of systemicity) was introduced for plant disease control. Fungal mutants selected for resistance to 1 member of this group of fungicides usually display resistance to other members as well. This phenomenon of cross-resistance indicates a common mode of action. Biochemical analysis of the toxic action of these compounds in fugal cells revealed that ergosterol biosynthesis is rapidly inhibited. This inhibition eventually curtails membrane synthesis and fungal growth. The details of the toxic action, effects on sterol biosynthesis, and sites of action of the sterol-inhibiting fungicides are discussed.This publication has 7 references indexed in Scilit:
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