Increased Plasma Gastrin Levels in Connection with Inhibition of Gastric Acid Responses to Sham Feeding Following Bulbar Perfusion with Acid in Dogs
- 1 May 1975
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 10 (3), 273-277
- https://doi.org/10.1080/00365521.1975.12096963
Abstract
Dogs were provided with oesophageal fistulae, fully innervated pouches of the fundic stomach and the duodenal bulb, and a gastric cannula. Gastric secretion was stimulated by sham feeding for 10 min. The bulbar pouches were perfused either with 0.9 per cent NaCl or with 0.1 N HCl. Plasma gastrin concentrations were determined by radioimmunoassay. Bulbar acidification effectively inhibited gastric acid secretion. Plasma gastrin responses were not suppressed. Instead, plasma gastrin concentrations were higher than in controls. The results show that the bulbar mechanism does not inhibit gastric acid secretion by reducing gastrin release.Keywords
This publication has 7 references indexed in Scilit:
- Effect of Antral Denervation on Gastrin Release by Sham Feeding and Insulin Hypoglycemia in DogsGastroenterology, 1972
- Plasma Gastrin and Gastric Acid Responses to Sham Feeding and Feeding in DogsGastroenterology, 1972
- Radioimmunoassay of gastrinGastroenterology, 1970
- Effect of Acid in the Duodenal Bulb on Gastric Secretory Responses to Sham Feeding1Acta Physiologica Scandinavica, 1969
- Effect of Acid in Proximal and Distal Duodenal Pouches on Gastric Secretory Responses to Gastrin and Histamine1Acta Physiologica Scandinavica, 1967
- The constitution and properties of two gastrins extracted from hog antral mucosa: Part I The isolation of two gastrins from hog antral mucosaGut, 1964
- Esophageal Cannula Dog, a Simple Mode of Preparation for Sham Feeding ExperimentsGastroenterology, 1959