The possible role of histamine in the cortisone induced gastric acid hypersecretion of the guinea‐pig

Abstract

1 The effects of cortisone treatment combined with agents influencing histamine metabolism were studied on the free and total acid output in pylorus ligated guinea-pigs. 2 It was found that reduction in the synthesis of histamine produced by the administration of α-methylDOPA significantly inhibited the acid response to cortisone. 3 Enhancement of the oxidative deamination of histamine brought about by the administration of diamine oxidase or heparin inhibited cortisone induced acid hypersecretion significantly. 4 Inhibition of the oxidative deamination of histamine by aminoguanidine and iproniazid resulted in a significant increase of the cortisone induced acid hypersecretory response. 5 Inhibition of the methylation of histamine by chlorpromazine or 1, 4-methylhistamine inhibited the cortisone induced hypersecretory response significantly. 6 Studies with labelled histamine indicated that cortisone increases the sequestration of histamine to the stomach.