The possible role of histamine in the cortisone induced gastric acid hypersecretion of the guinea‐pig
Open Access
- 1 March 1969
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 35 (3), 498-509
- https://doi.org/10.1111/j.1476-5381.1969.tb08291.x
Abstract
1 The effects of cortisone treatment combined with agents influencing histamine metabolism were studied on the free and total acid output in pylorus ligated guinea-pigs. 2 It was found that reduction in the synthesis of histamine produced by the administration of α-methylDOPA significantly inhibited the acid response to cortisone. 3 Enhancement of the oxidative deamination of histamine brought about by the administration of diamine oxidase or heparin inhibited cortisone induced acid hypersecretion significantly. 4 Inhibition of the oxidative deamination of histamine by aminoguanidine and iproniazid resulted in a significant increase of the cortisone induced acid hypersecretory response. 5 Inhibition of the methylation of histamine by chlorpromazine or 1, 4-methylhistamine inhibited the cortisone induced hypersecretory response significantly. 6 Studies with labelled histamine indicated that cortisone increases the sequestration of histamine to the stomach.Keywords
This publication has 26 references indexed in Scilit:
- Effects of cortisone on parietal cells and acid secretion in dogsJournal of Surgical Research, 1967
- Histamin und Histidindecarboxylasen im oberen Verdauungstrakt von Mensch, Hund, Meerschweinchen und RatteNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1967
- The effect of heparin on gastric secretion stimulated by histamine or ametazole hydrochlorideJournal of Pharmacy and Pharmacology, 1966
- Heparin‐induced Diamine Oxidase Increase in Human Blood PlasmaActa Medica Scandinavica, 1966
- The Influence of Aminoguanidine and Heparin on Shock in Guinea-PigsInternational Archives of Allergy and Immunology, 1965
- Histaminase in Shock in Guinea-PigsInternational Archives of Allergy and Immunology, 1965
- Purification and identification of hog-kidney histaminaseBiochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1963
- Characteristics of mammalian histidine decarboxylating enzymesBiochimica et Biophysica Acta, 1961
- The influence of cortisone on the parietal cell population of the stomach in the dogGut, 1961
- The Effects of Corticotrophin and Corticoids on Secretion from Denervated Gastric Pouches in DogsGut, 1960