Identification of a clinical subset of systemic lupus erythematosus by antibodies to the sm antigen
Open Access
- 1 December 1979
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 22 (12), 1334-1337
- https://doi.org/10.1002/art.1780221203
Abstract
The clinical and renal histologic attributes of 135 systemic lupus erythematosus (SLE) patients with DNA and/or Sm antibodies were compared to determine if the presence of the Sm antibodies served as a marker for a specific subset of SLE. Although Raynaud's phenomenon was more frequent in patients with Sm antibodies (P < 0.005), serious central nervous system disease was over three times as common in patients with DNA antibodies (P < 0.005). Only one of 23 patients with Sm antibodies had diffuse proliferative glomerulonephritis on renal biopsy, whereas 6 of 14 patients with only DNA antibodies had this histologic finding (P = 0.01). The Sm antibody system may therefore identify a subset of SLE patients with milder central nervous system and renal disease.This publication has 13 references indexed in Scilit:
- MEMBRANOUS LUPUS NEPHROPATHYMedicine, 1977
- An immunofluorescent method using crithidia luciliae to detect antibodies to double‐stranded DNAArthritis & Rheumatism, 1977
- DNA-binding property of Sm nuclear antigen.The Journal of Experimental Medicine, 1977
- Antinuclear antibody with distinct specificity for polymyositis.JCI Insight, 1977
- Association of Antibodies to Ribonucleoprotein and Sm Antigens with Mixed Connective-Tissue Disease, Systemic Lupus Erythematosus and Other Rheumatic DiseasesNew England Journal of Medicine, 1976
- The Glomerular Complement Receptor in Immunologically Mediated Renal Glomerular InjuryNew England Journal of Medicine, 1976
- Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresisArthritis & Rheumatism, 1976
- Extractable nuclear antigen effect on the DNA anti-DNA reaction and NZB/NZW mouse nephritis.JCI Insight, 1975
- The Choroid Plexus in Systemic Lupus ErythematosusAnnals of Internal Medicine, 1972
- THE REACTION OF THE LUPUS ERYTHEMATOSUS (L.E.) CELL FACTOR WITH DEOXYRIBONUCLEOPROTEIN OF THE CELL NUCLEUSJCI Insight, 1959