Vasopressin antagonist analogs modified at position 7
- 1 October 1986
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 28 (4), 379-385
- https://doi.org/10.1111/j.1399-3011.1986.tb03269.x
Abstract
Vasopressin antagonist analogs having alanine or glycine at position 7 were essentially equipotent with analogs with proline, N-methylalanine or sarcosine at position 7. This demonstrates that the conformational constraint imposed by an N-alkyl residue at position 7 is not necessary for binding of antagonist to the receptor, the exact opposite of what is seen in agonists. This suggests that antagonists bind to the receptor in a manner which is very different from that of agonists.Keywords
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