Distribution of C14-Labeled Alloxan in the Tissues of the Rat and its Mode of Elimination.

Abstract

Two alloxan prepns., labeled in the 2- and in the 5-position with C14, were admd. subcut. to rats. Both were rapidly excreted in the urine, to the extent of 90-95% in 22 hrs. Negligible portions of the Cl4 were found in urea. The radioactivity was highest in the kidneys and plasma and reached a peak in approx. 15 min. Other tissues including the pancreas, had much lower radioactivity. Very little C14O2 appeared in expired air. The alloxan molecule apparently does not undergo extensive catabolism in the rat.