URETHANE-INDUCED LYMPHOPENIA IN NORMAL AND ADRENALECTOMIZED RATS

Abstract

A leucopenia and an absolute lymphopenia of similar magnitude was induced in normal intact and normal adrenalectomized rats following the intra-perit. admn. of a 10% urethane soln. The evidence presented here showed that the adrenal glands were not involved in these changes in the blood picture. A possible mode of urethane action was discussed. A relation of urethane with the adrenal mechanism was suggested by a polymorpho-leu-cocytosis which was induced in urethanized rats 20 hr. after adrenal cortical stimulation.