T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
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Open Access
- 1 March 2011
- journal article
- clinical trial
- Published by Elsevier in Molecular Therapy
- Vol. 19 (3), 620-626
- https://doi.org/10.1038/mt.2010.272
Abstract
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This publication has 32 references indexed in Scilit:
- A Phase I Study of a Combination of Yttrium-90–Labeled Anti–Carcinoembryonic Antigen (CEA) Antibody and Gemcitabine in Patients with CEA-Producing Advanced MalignanciesClinical Cancer Research, 2009
- Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer CellsClinical Cancer Research, 2008
- A Phase I Study of Hyperthermic Isolated Hepatic Perfusion with Oxaliplatin in the Treatment of Unresectable Liver Metastases from Colorectal CancerAnnals of Surgical Oncology, 2008
- Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative RegimensJournal of Clinical Oncology, 2008
- Balancing between Antitumor Efficacy and Autoimmune Pathology in T-Cell–Mediated Targeting of Carcinoembryonic AntigenCancer Research, 2008
- The tumor microenvironment and its role in promoting tumor growthOncogene, 2008
- Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell FunctionsThe Journal of Immunology, 2008
- Toll-like Receptors in Tumor ImmunotherapyClinical Cancer Research, 2007
- Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 StabilityCancer Research, 2006
- Redirection of T Cells by Delivering a Transgenic Mouse-Derived MDM2 Tumor Antigen-Specific TCR and its Humanized Derviative Is Governed by the CD8 Coreceptor and Affects Natural Human TCR ExpressionImmunologic Research, 2006