Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells
Open Access
- 1 July 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (27), 24799-24808
- https://doi.org/10.1074/jbc.m112424200
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-noneneJournal of Biological Chemistry, 2001
- Tumorigenicity of Fjord Region Diol Epoxides of Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Compounds, 1996
- Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon o-quinones produced by dihydrodiol dehydrogenaseChemico-Biological Interactions, 1996
- Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a, l]pyrene (dibenzo[def, p]chrysene), 4H-cyclopenta[def]chrysene and fluorantheneCarcinogenesis: Integrative Cancer Research, 1995
- Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dioneChemico-Biological Interactions, 1992
- Activation of the Ki-ras gene in spontaneous and chemically induced lung tumors in CD-1 miceMolecular Carcinogenesis, 1992
- Trapping of a carbocationic intermediate in the spontaneous hydrolysis reaction of 7.beta.,8.alpha.-dihydroxy-9.beta.,10.beta.-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene: mechanism of the spontaneous and general acid catalyzed hydrolysis reactions of bay-region benzo[a]pyrene 7,8-diol 9,10-epoxidesJournal of the American Chemical Society, 1990
- Synthesis of optically active fjord-region 11,12-diol 13,14-epoxides and the K-region 9,10-oxide of the carcinogen benzo[g]chryseneThe Journal of Organic Chemistry, 1989
- Synthesis of the active diol epoxide metabolites of the potent carcinogenic hydrocarbon 7,12-dimethylbenz[a]anthreneThe Journal of Organic Chemistry, 1986
- Synthesis of the non-K-region o-quinones and dihydrodiols of polycyclic aromatic hydrocarbons from the corresponding phenolsThe Journal of Organic Chemistry, 1980