Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
- 27 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4170), 1213-1215
- https://doi.org/10.1126/science.186.4170.1213
Abstract
In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical evaluation reveals a marked decrease in plasma dihydrotestosterone secondary to a decrease in steroid 5α-reductase activity. In utero the decrease in dihydrotestosterone results in incomplete masculinization of the external genitalia. Inheritance is autosomal recessive.Keywords
This publication has 9 references indexed in Scilit:
- Steroid Pathways in Sebaceous GlandsJournal of Investigative Dermatology, 1974
- Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human EmbryoJournal of Clinical Endocrinology & Metabolism, 1974
- Copulation in Castrated Male Rats following Combined Treatment with Estradiol and DihydrotestosteroneScience, 1973
- In Vitro Synthesis of Mullerian-Inhibiting Hormone by Seminiferous Tubules Isolated from the Calf Fetal TestisEndocrinology, 1973
- Testosterone Cytosol “Receptor” in the Rat Levator Ani MuscleNature New Biology, 1972
- The Source of Plasma Dihydrotestosterone in ManJournal of Clinical Investigation, 1971
- The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediolsJournal of Clinical Investigation, 1971
- Measurement of Testosterone and 17-Ketosteroids in Plasma by the Double Isotope Dilution Derivative Technique1Journal of Clinical Endocrinology & Metabolism, 1968
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951