HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF RANITIDINE IN PLASMA AND URINE
- 1 October 1988
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 13 (5), 351-357
- https://doi.org/10.1111/j.1365-2710.1988.tb00204.x
Abstract
A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0·05 m ammonium acetate buffer containing 0·01 m octane sulphonate, 5·3%; methanol, 31·6%; and acetonitrile, 63·1%. Detection was carried out at 330 nm. Metoclopramide was used as the internal standard. Peak height ratios were measured. Absolute recovery from plasma was 83–85%. Within and between day coefficients of variation ranged from 0·79 to 2·42% and 1·09–2·95% respectively. Plasma and urine samples from a healthy volunteer were analysed.This publication has 6 references indexed in Scilit:
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