Chronic Lymphocytic Leukemia and Lymphosarcoma Associated With Multiple Myeloma

Abstract

The association of multiple myeloma with other hematologic diseases, such as polycythemia vera, macroglobulinemia, and "immunoproliferative disorders," is rare, but recognized.¹ The simultaneous occurrence of multiple myeloma and chronic lymphocytic leukemia or lymphosarcoma is also extremely rare.^2-6 This report describes three patients with both diseases and discusses the question as to whether these two diseases represent part of the spectrum of a single B-cell disease or whether multiple myeloma and lymphoproliferative diseases are two separate entities that may rarely occur by coincidence in the same patient. PATIENT SUMMARIES Patient1. —A 67-year-old man was hospitalized because of fever, cough, sore throat, and left anterior lower chest pain, of one week's duration.⁴ Six years earlier, the patient felt a mass behind the left ear, but he did not seek medical attention. The patient developed a positive tuberculin reaction four months prior to admission, following exposure to his wife