A METHOD FOR MEASURING THE ACTIVITY OF COMPOUNDS WITH AN ACTIVITY LIKE VITAMIN K AGAINST INDIRECT ANTICOAGULANTS IN RATS
Open Access
- 1 March 1959
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (1), 14-18
- https://doi.org/10.1111/j.1476-5381.1959.tb00922.x
Abstract
A method for the estimation of the activity of compounds like vitamin K using rats treated with an indirect anticoagulant is described. The assay measured the speed of onset and magnitude of the antidotal effect. Under the conditions employed, only vitamin K1 produced a significant response. Vitamin K3 and its water-soluble derivatives were inactive. Both the magnitude and the speed of onset of the antidotal effect of vitamin K1 were found to depend on the extent to which it was in solution. The assay gave results of fair accuracy and reproducibility, which permitted a full statistical analysis and provided an estimate of error.Keywords
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