Platelet Serotonin Uptake and Migraine

Abstract

Platelet serotonin uptake characm, max, y) were determined in platelet-rich plasma for 11 common migraineurs and 15 healthy volunteers. All three parameters decreased only for the three patients having a migraine collection. Migrainous platelets isolated on dextran or resuspended in control plasma exhibited normal serotonin uptake. This finding suggests that plasmatic factor(s) may be responsible for the decrease of platelet serotonin uptake observed during migraine attack.