Invited Review: Repair of DNA Damage Induced by Reactive Oxygen Species
- 1 January 1991
- journal article
- other
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 14 (3), 159-171
- https://doi.org/10.3109/10715769109088945
Abstract
DNA repair limits the mutagenic, and thereby the carcinogenic, effect of DNA modifications. Free radicals, particularly reactive oxygen species, induce all forms of DNA damage, including base modifications, base free sites, strand breakage, and cross-links. These lesions are repaired by a variety of enzymes of partly overlapping substrate specificity, some of which may be induced.Keywords
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