Further Studies on the Acute Toxicity of Mercurial Diuretics.

Abstract

Mercuric chloride, Salyrgan-theophylline, Mer-cuzanthin, Mercuhydrin and N-a-carboxymethylmercapto-mercuri-[beta]-methoxy propyl camphoramic acid disodium salt (MT6) have been compared with respect to their ability to cause cardiac toxicity as manifested by changes in the electrocardiogram of the cat. The toxicity decreases in the order named. Compound MT6 causes no immediate changes in the electrocardiogram in doses up to 160 times the maximum tolerated dose of Mercuhydrin, otherwise the least toxic of the mercurials studied. This improvement appears to be due to the relatively greater stability of the mercaptide as compared with the theophylline complex.