The Role of Complement in Allergen-Reagin Mediated Histamine Release from Monkey Lung Tissue

Abstract

Summary Both C3 inactivator isolated from human sera and rabbit antihuman C3 sera markedly inhibit allergen induced, histamine release from monkey lung tissue passively sensitized with human reagin. These studies suggest that C3 participates in allergic reactions without the prior action of C1, C4, and C2 and that monkey lung tissue has distinct receptor sites for both C3 and human reagin.