Determination of Valproic Acid by Flame-Ionization Gas-Liquid Chromatography
- 1 May 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 3 (3), 108-110
- https://doi.org/10.1093/jat/3.3.108
Abstract
A rapid method is described for determination of valproic acid in biologic fluids by utilization of a gas chromatograph equipped with a flame-ionization detector. After caproic acid is added to the biologic specimen as an internal standard, the specimen is extracted with 10% ethyl acetate in hexane, followed by direct chromatographic analysis using an SP-1000 liquid-phase column. The procedure does not require solvent evaporation. Recovery of the drug is approximately 100%. Inter-assay coefficient of variation is less than 4%.This publication has 5 references indexed in Scilit:
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