Hsp70 in mitochondrial biogenesis: From chaperoning nascent polypeptide chains to facilitation of protein degradation
- 1 November 1994
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 50 (11-12), 1002-1011
- https://doi.org/10.1007/bf01923454
Abstract
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix.Keywords
This publication has 60 references indexed in Scilit:
- YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functionsFEBS Letters, 1994
- The requirement of matrix ATP for the import of precursor proteins into the mitochondrial matrix and intermembrane spaceEuropean Journal of Biochemistry, 1994
- Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homolog of E. coli groESFEBS Letters, 1993
- Yeast mitochondrial ATP‐dependent protease: purification and comparison with the homologous rat enzyme and the bacterial ATP‐dependent protease LaFEBS Letters, 1993
- YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanismCell, 1992
- The translation machinery and 70 kd heat shock protein cooperate in protein synthesisCell, 1992
- Polypeptides traverse the mitochondrial envelope in an extended stateFEBS Letters, 1990
- Molecular structure of flavocytochrome b2 at 24 Å resolutionJournal of Molecular Biology, 1990
- THE HEAT-SHOCK PROTEINSAnnual Review of Genetics, 1988
- Speculations on the functions of the major heat shock and glucose-regulated proteinsCell, 1986