Binding of optically pure (−)‐[3H]nicotine to rat brain membranes
- 27 June 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 157 (1), 147-149
- https://doi.org/10.1016/0014-5793(83)81134-x
Abstract
With the recent availability of (−)-[3H]nicotine of high specific activity, binding studies were performed on rat brain membranes in the presence of a variety of nicotine analogues and cholinergic drugs. Both a higher affinity (K d = 2 × 10−10 M) and a lower affinity (2 × 10−9 M) site were observed; the stereoselectivity of both sites being similar. A good correlation was observed between IC 50-values and psychotropic potency of a series of N′-alkyl substituted nicotine analogues.Keywords
This publication has 9 references indexed in Scilit:
- Sites and mechanisms for nicotine's action in the brainNeuroscience & Biobehavioral Reviews, 1981
- Noncholinergic, Saturable Binding of (±)-[3H]Nicotine to Mouse BrainJournal of Receptor Research, 1981
- Stereospecific Nicotine Receptors on Rat Brain MembranesScience, 1980
- Stereospecific 3H-nicotine binding to intact and solubilized rat brain membranes and evidence for its noncholinergic natureLife Sciences, 1980
- Synthesis and preliminary binding studies of 4,4-ditritio-(-)-nicotine of high specific activityJournal of Medicinal Chemistry, 1980
- Separation of d -(+)-Nicotine from a Racemic Mixture by Stereospecific Degradation of the l -(−) Isomer with Pseudomonas putidaApplied and Environmental Microbiology, 1980
- Convenient syntheses of N-CD3 labelled nicotine and nicotine analoguesJournal of Labelled Compounds and Radiopharmaceuticals, 1979
- Analogues of sparteine. II. Synthesis of N-monoalkylbispidines and N,N'-dialkylbispidinesThe Journal of Organic Chemistry, 1976