Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers
Open Access
- 1 January 2019
- journal article
- review article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 9 (11), 3280-3292
- https://doi.org/10.7150/thno.34412
Abstract
Protein delivery into cells is a potentially transformative tool for treating “undruggable” targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for proteins with therapeutic and diagnostic relevance. In this review we will present promising non-viral approaches for intracellular and ultimately cytosolic delivery of proteins using nanocarriers. We will also discuss the mechanistic properties that govern the efficacy of nanocarrier-mediated protein delivery, applications of nanomaterials, and key challenges and opportunities in the use of nanocarriers for intracellular protein delivery.Keywords
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