GENES OF STRESS IN EXPERIMENTAL HYPERTENSION
- 1 November 1994
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 21 (11), 907-911
- https://doi.org/10.1111/j.1440-1681.1994.tb02464.x
Abstract
1. A significant portion of blood pressure variance is modified by the environment. 2. The present report summarizes evidence that: (i) the environmental response is genetically determined; (ii) various stressors can evoke a differential response in hypertensive animals and constitute its intermediate phenotypes; (iii) the response to heat stress can be assigned to a single ‘thermosensitivity’ locus; (iv) candidate genes of susceptibility to environmental stresses are member(s) of the heat stress gene (HSP) gene families; (v) a restriction fragment length polymorphism ofhsp70 and a single base mutation in the 3′‐untranslated region of hsp27 are associated with hypertension in recombinant inbred strains. 3. In conclusion, HSP gene variants may be causative in susceptibility to hypertension.Keywords
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