Perioperative Stress Response in the Dog: Effect of Pre‐Emptive Administration of Medetomidine
- 1 January 2000
- journal article
- clinical trial
- Published by Wiley in Veterinary Surgery
- Vol. 29 (1), 85-91
- https://doi.org/10.1111/j.1532-950x.2000.00085.x
Abstract
Objective— To determine the effect of medetomidine on the stress response induced by ovariohysterectomy in isoflurane‐anesthetized dogs. Study Design— Prospective randomized study. Animals— Twelve healthy adult female purpose‐bred dogs, weighing 16.8 to 25 kg. Methods— Two treatments were randomly administered to each of twelve dogs at weekly intervals: (1) Saline injected IM followed in 15 minutes by isoflurane anesthesia (ISO) induced by mask and maintained at an end‐tidal concentration of 1.8% for 60 minutes; and (2) Medetomidine, 15 μg/kg IM followed in 15 minutes by isoflurane anesthesia (ISO & MED) induced by mask and maintained at an end‐tidal concentration of 1.0% for 60 minutes. One week after completion of these two treatments, all dogs were ovariohysterectomized, six receiving each treatment (SURG and SURG&MED). Central venous blood samples (10 mL) were obtained immediately before medetomidine or saline (baseline) and at 30, 75, and 195 minutes and 24 hours after administration of medetomidine or saline in ISO and ISO&MED. In SURG and SURG&MED, samples were obtained immediately prior to injection of medetomidine or saline (baseline) and at 30 (before skin incision), 45 (after severence of the ovarian ligament), 75 (after skin closure), 105 (30 minutes after skin closure, dog recovered and in sternal recumbency), 135, 195, 375 minutes, and 24 hours after the initial sample. Samples were analyzed for epinephrine, norepinephrine, adrenocorticotrophic hormone (ACTH), cortisol, insulin, and glucose. Data were analyzed by analysis of variance and where significant differences were found, a least significant difference test was applied. Results— Premedication with medetomidine prevented or delayed the stress response induced by ovariohysterectomy in isoflurane‐anesthetized dogs. Conclusions— The stress response induced by ovariohysterectomy, although significant, is of short duration. Medetomidine safely and effectively reduced surgically‐induced stress responses. Clinical Relevance— Surgically induced stress responses can be obtunded or prevented by administration of medetomidine.Keywords
This publication has 8 references indexed in Scilit:
- Changes in plasma cortisol concentrations before, during and after analgesia, anaesthesia and anaesthesia plus ovariohysterectomy in bitchesResearch in Veterinary Science, 1994
- Effect of non-adrenal illness, anaesthesia and surgery on plasma cortisol concentrations in dogsResearch in Veterinary Science, 1994
- Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central SensitizationAnesthesia & Analgesia, 1993
- Postoperative Catecholamine Response to Onychectomy in Isoflurane-anesthetized Cats Effect of AnalgesicsVeterinary Surgery, 1991
- Alpha-2 Adrenoceptor AgonistsAnesthesiology, 1991
- RECENT ADVANCES IN THE PATHOPHYSIOLOGY OF ACUTE PAINBritish Journal of Anaesthesia, 1989
- Should We All Have a Sympathectomy at Birth? Or at Least Preoperatively?Anesthesiology, 1988
- The Importance of the Brain in the Endocrine Response to InjuryAnnals of Surgery, 1959