Clinical and positron emission tomography of Parkinson's disease caused by LRRK2
- 24 February 2005
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 57 (3), 453-456
- https://doi.org/10.1002/ana.20401
Abstract
We have recently identified mutations in a gene leucine‐rich repeat kinase–2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6‐18F‐fluoro‐L‐dopa positron emission tomography and discuss the potential implications of this mutation, which alters a conserved residue in a domain required for kinase activation. Ann Neurol 2005;57:453–456Keywords
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