Coronary Heart Disease Risk Factors in Men and Women Aged 60 Years and Older
- 1 July 1996
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 94 (1), 26-34
- https://doi.org/10.1161/01.cir.94.1.26
Abstract
Background Coronary heart disease (CHD) is the most common cause of death in men and women aged 60 years and older. Although a number of studies support the concept that CHD risk factors that have been defined in younger adults are significantly associated with CHD events in older adults, others do not support this thesis, and further definition of the risk-factor concept in older adults is required. Methods and Results The Systolic Hypertension in the Elderly Program recruited 4736 persons (mean age, 72 years); 14% were black, and 43% were men. Mean systolic and diastolic blood pressures were 170 and 77 mm Hg, respectively. About 13% of participants were current smokers; 10% had a history of diabetes; 5%, a prior myocardial infarction; 5%, angina pectoris; 2.3%, intermittent claudication; and 7%, a carotid bruit. Mean total cholesterol value was 6.11 mmol/L. Mean follow-up was 4.5 years. In multivariate Cox regression analyses for CHD, variables that were significant were baseline total cholesterol value, smoking, history of diabetes, presence of carotid bruit, and treatment group in the trial. Active treatment yielded a 27% reduction in CHD risk. For each 1.03 mmol/L increase in total cholesterol value, there was an increase in risk of about 20%. Current smokers had a 73% increase, diabetics a 121% increase, and those with carotid bruit a 113% increase in CHD risk. Conclusions The results of this study support the concept that CHD risk factors are important in older men and women with isolated systolic hypertension.Keywords
This publication has 45 references indexed in Scilit:
- Systolic Hypertension in the Elderly Program (SHEP). Part 6: Baseline physical examination findings.Hypertension, 1991
- Systolic Hypertension in the Elderly Program (SHEP). Part 4: Baseline medical history findings.Hypertension, 1991
- Systolic Hypertension in the Elderly Program (SHEP). Part 8: Electrocardiographic characteristics.Hypertension, 1991
- Systolic Hypertension in the Elderly Program (SHEP). Part 7: Baseline laboratory characteristics.Hypertension, 1991
- Ten-Year Mortality from Cardiovascular Disease in Relation to Cholesterol Level among Men with and without Preexisting Cardiovascular DiseaseNew England Journal of Medicine, 1990
- Beneficial Six-Year Outcome of Smoking Cessation in Older Men and Women with Coronary Artery DiseaseNew England Journal of Medicine, 1988
- Ischemic heart disease risk factors after age 50Journal of Chronic Diseases, 1984
- Risk of Stroke in Asymptomatic Persons with Cervical Arterial BruitsNew England Journal of Medicine, 1980
- Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the pooling projectJournal of Chronic Diseases, 1978
- The interrelationship of serum cholesterol, hypertension, body weight, and risk of coronary disease: Results of the first ten years' follow-up in the Los Angeles Heart StudyJournal of Chronic Diseases, 1964