Effect of Commercial Cortisone Acetate Suspension on Capillary Permeability

Abstract

Cortisone acetate induces a rapid increase in capillary permeability. The reaction is prompt and constant. The gross picture displays fairly large sediments of the material at the site of injn. whereas the microscopic picture reveals in the treated area numerous congested vessels. This appearance is probably referable to the prompt seepage of plasma with the induced increase in capillary permeability. ACTH fails to have a similar local effect. There is no detectable effect in increasing capillary permeability when ACTH is substituted for cortisone suspension. The effect of cortisone suspension on capillary structures can be detected when 500 [mu]g. of the material is utilized. The increased capillary permeability induced does not seem to be referable to cortisone but rather to the vehicle in which cortisone acetate is suspended. Cortisone powder fails to increase capillary permeability.