The growing applications of click chemistry
Top Cited Papers
- 3 May 2007
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 36 (8), 1249-1262
- https://doi.org/10.1039/b613014n
Abstract
Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon–heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.Keywords
This publication has 41 references indexed in Scilit:
- In situclick chemistry: a powerful means for lead discoveryExpert Opinion on Drug Discovery, 2006
- Click Chemistry as a Reliable Method for the High-Density Postsynthetic Functionalization of Alkyne-Modified DNAOrganic Letters, 2006
- CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic PerspectiveEuropean Journal of Organic Chemistry, 2005
- Peptide ligation through click chemistry for the generation of assembled and scaffolded peptidesTetrahedron Letters, 2005
- Polytriazoles as Copper(I)-Stabilizing Ligands in CatalysisOrganic Letters, 2004
- The growing impact of click chemistry on drug discoveryDrug Discovery Today, 2003
- Azide–Alkyne Coupling: A Powerful Reaction for Bioconjugate ChemistryChemBioChem, 2003
- A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal AlkynesAngewandte Chemie International Edition, 2002
- Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to AzidesThe Journal of Organic Chemistry, 2002
- Click Chemistry: Diverse Chemical Function from a Few Good ReactionsAngewandte Chemie International Edition, 2001