Immunofluorescent patterns in the skin in Besnier's prurigo.
- 1 April 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 96 (4), 357-380
- https://doi.org/10.1111/j.1365-2133.1977.tb07129.x
Abstract
The immunofluorescent patterns in the skin of 18 patients with Besnier''s prurigo were studied at different stages of eczematous lesions. The presence, distribution pattern and numbers of immunoglobulin [Ig] and complement-positive lymphocytes in 29 biopsies were reported. In all cases IgE-positive lymphocytes were present in both clinically uninvolved and involved skin. IgG, IgM and IgE-positive lymphocytes showed a characteristic distribution pattern in the dermis. In the acute stages IgM deposition was prominent in the basement membrane zone; damage to the basement membrane probably resulted in diffusion of Ig and complement into the epidermis. These features were not present in a control group of normal skin and of other dermatoses.This publication has 6 references indexed in Scilit:
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- Immunoglobulin- and complement-bearing lymphocytes in allergic contact dermatitis and atopic dermatitis (eczema)*British Journal of Dermatology, 1974
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