ACUTE EFFECTS OF ETHANOL ON TISSUE ELECTROLYTES IN THE RAT
- 1 January 1966
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 44 (1), 1-12
- https://doi.org/10.1139/y66-001
Abstract
Groups of Wistar albino rats of both sexes received either gavage with low or high doses of water, ethanol in water, or no treatment. Ninety minutes later they were decapitated and exsanguinated, and samples of brain, ventricular myocardium, renal cortex, liver, skeletal muscle, whole blood, and plasma were obtained. These were analyzed for water, chloride, sodium, and potassium. Corrections were made for residual blood in the heart, kidney, and liver samples. On the basis of an assumed extracellular location of chloride, the intracellular content of water and the concentrations of sodium and potassium in the intracellular water (i.e., chloride-free space) were calculated.All treatments produced a fall in the water content of the blood and a rise in potassium, which were taken as evidence of hemoconcentration. The plasma showed a fall in sodium, which was most marked following the high dose of water and was interpreted as a dilution effect; and a fall in potassium after ethanol, which is not yet explained. Most tissues tended to show a rise in calculated intracellular water and sodium and a fall in intracellular potassium after ethanol, especially after the high dose (4 g/kg). These changes, although statistically significant only in liver and kidney, are compatible with data reported elsewhere which show that ethanol inhibits the active transport of cations across cell membranes.This publication has 8 references indexed in Scilit:
- Effect of ethanol on electrolyte transport and electrogenesis in animal tissuesJournal of Cellular and Comparative Physiology, 1965
- Effect of Ethanol on the Transport of Sodium in Frog SkinNature, 1963
- THE EFFECT OF REPEATED ALCOHOLIC INTOXICATION ON ADRENAL ASCORBIC ACID AND CHOLESTEROL IN THE RATCanadian Journal of Biochemistry and Physiology, 1962
- THE EFFECT OF ACUTE ALCOHOLIC INTOXICATION ON ADRENAL ASCORBIC ACID AND CHOLESTEROL IN THE RATCanadian Journal of Biochemistry and Physiology, 1961
- SOME EFFECTS OF ALCOHOL ON WATER AND ELECTROLYTES IN THE DOG1957
- STUDIES ON ALCOHOL DIURESIS. I. THE EFFECT OF ETHYL ALCOHOL INGESTION ON WATER, ELECTROLYTE AND ACID-BASE METABOLISM 12JCI Insight, 1955
- Water and Electrolyte MetabolismPhysiological Reviews, 1954
- THE EFFECT OF ALCOHOL ON THE RENAL EXCRETION OF WATER AND ELECTROLYTE 1JCI Insight, 1950