Physical properties of chemically acetylated rat liver chromatin.
- 1 August 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (8), 3244-3248
- https://doi.org/10.1073/pnas.74.8.3244
Abstract
The physical properties of rat liver chromatin and nucleosomes acetylated with acetic anhydride were examined in order to clarify the mechanism by which chemical acetylation of histones increases template activity in vitro. Acetylation had dramatic effects on the Mg solubility, nuclease sensitivity, thermal denaturation and sedimentation of chromatin and nucleosomes. The significance of the results to models of gene activation and chromatin replication is considered.This publication has 27 references indexed in Scilit:
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