Anti-IgG Activity on Peripheral Blood Lymphocytes in Psoriasis

Abstract

Using the rheumatoid rosette test that detects rheumatoid factor at the cellular level, we have studied 30 patients with complicated or uncomplicated psoriasis, 20 patients with eczema, and 153 control subjects with miscellaneous nondermatologic diseases. Less than six rosettes per 1,000 lymphocytes (negative test) were found in 96% of 153 control subjects, while in 30 patients with psoriasis, there were 40% of positive rheumatoid rosette tests (more than six rosettes per 1,000 lymphocytes). In all subjects with eczema the test was negative. The significance of the finding of an anti-IgG activity in psoriasis is discussed. Cellmediated immunologic disorders, not previously described, seem present in this disease.