Stable Complex of Fibrinogen and Fibrin
- 20 May 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3725), 1069-1071
- https://doi.org/10.1126/science.152.3725.1069
Abstract
Fibrin-stabilizing factor acts on monomeric fibrin combined with fibrinogen to form a stable complex that is soluble at physiologic p H and ionic strength. The complex has been isolated by chromatography on agarose gel and characterized by sedimentation rate near 24 S w.20 at both p H 5.3 and 7.4, by coagulability when treated with thrombin, and by content of fibrinopeptides. Formation of the complex could provide a pathway for solubilization of monomeric fibrin produced in circulating blood.Keywords
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