S100a0 (αα) Protein Is Present in Neurons of the Central and Peripheral Nervous System

Abstract

The cellular distribution of S100 subunits in human brain and peripheral nerves was studied by means of an immunohistochemical technique using antibodies specific to the a subunit or the β subunit of S100 protein. The results indicate that the distribution of the a subunit and the β subunit is different among cell types in the nervous tissue, and that neurons in the brain and peripheral nerves contain only the a subunit, or S100a₀ protein. The subunit distribution also appears to be different at an intracellular level, where the immunoreaction products for the a subunit show granular arrangement whereas those for the β subunit are found diffusely in the cytoplasm.