Inhibition of Carbonic Anhydrase: Effect on Tissue Gas Tensions in the Rat

Abstract

The PCO2 of subcutaneous gas pockets in rats rose 8.6 mm Hg 30 minutes after carbonic anhydrase inhibition by acetazolamide (50 mg/kg intra-peritoneally). There was no change in PO2. There was an associated hyperventilation and 4 vol. percent rise in arterial CO2 content. Control studies showed no change. Results are interpreted as evidence of a rise in venous and tissue PCO2 following carbonic anhydrase inhibition.