Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects
- 1 January 1991
- journal article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 8 (3), 360-364
- https://doi.org/10.1023/a:1015849700421
Abstract
The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male volunteers after repeated weekly administration. The dosage forms were labeled with gamma-emitting radionuclides and the transit of the formulations was monitored on 4 separate study days using the technique of dual-isotope gamma scintigraphy. Gastric emptying times and small intestinal transit times were calculated and compared statistically within and between subjects using the standard deviation and coefficient of variance. The variability in gastric emptying of single- and multiple-unit systems was large; the intrasubject variation being less than the intersubject. There was less variation in small intestinal transit times for the single- and multiple-unit formulations than in gastric emptying, intrasubject variation again being less than intersubject variation.Keywords
This publication has 14 references indexed in Scilit:
- Inter‐ and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption.British Journal of Clinical Pharmacology, 1990
- Gastric emptying of large single unit dosage formsJournal of Pharmacy and Pharmacology, 1988
- Exercise and small intestinal transitNuclear Medicine Communications, 1987
- The effect of polycarbophil on the gastric emptying of pelletsJournal of Pharmacy and Pharmacology, 1987
- Transit of pharmaceutical dosage forms through the small intestine.Gut, 1986
- Variability of gastric emptying measurements in man employing standardized radiolabeled mealsDigestive Diseases and Sciences, 1986
- The effect of density on the gastric emptying of single- and multiple-unit dosage formsPharmaceutical Research, 1986
- The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulationsJournal of Pharmacy and Pharmacology, 1985
- Canine gastric emptying of solids and liquids.American Journal of Physiology-Endocrinology and Metabolism, 1977
- The interdigestive myo‐electric complex of the stomach and small bowel of dogs.The Journal of Physiology, 1975