Phenylketonuria: Enduring Behavioral Deficits in Phenylketonuric Rats
- 24 February 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 155 (3765), 1033-1035
- https://doi.org/10.1126/science.155.3765.1033
Abstract
The behavioral deficit in rats made "phenylketonuric" by ingestion of L-phenylalanine was evaluated 23 to 65 days following cessation of treatment. Animals treated from birth to 60 days showed significant deficit on reasoning and discrimination learning tests but not on discrimination reversal sets. Animals treated from 30 to 60 days showed significant deficit only on the reasoning test.This publication has 9 references indexed in Scilit:
- Phenylketonuria in Rats: Reversibility of a Behavioral DeficitScience, 1966
- Effects on rat offspring of maternal phenylalanine diet during pregnancyJournal of Psychiatric Research, 1965
- The relative difficulty of reversal learning (reversal index) as a basis of behavioural comparisonsAnimal Behaviour, 1965
- Experimental attempts to produce phenylketonuria in animals: A critical review.Psychological Bulletin, 1965
- Unimpaired Learning Ability of Rats Made Artificially Phenylketonuric During Fetal or Neonatal Life.Experimental Biology and Medicine, 1965
- A COMPREHENSIVE METHOD FOR THE DETERMINATION OF URINARY CHLORPROMAZINE AND ITS OXIDATIVE METABOLITESAmerican Journal of Psychiatry, 1963
- Effect of Phenylalanine Diet on Learning in the RatNature, 1962
- Discrimination learning as a function of reversal and nonreversal shifts.Journal of Experimental Psychology, 1956
- Cortical destruction of the posterior part of the brain and its effect on reasoning in ratsJournal of Comparative Neurology, 1932